Sally N Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn M Rexrode, Connection between intakes regarding magnesium, potassium, and you may calcium and you can chance of stroke: 2 cohorts people lady and you may current meta-analyses, The latest Western Journal from Health-related Diet, Volume 101, Issue 6, , Users 1269–1277,

Conceptual

Background: Potential study into loved ones off magnesium, potassium, and you will calcium supplements consumption that have heart attack risk are contradictory, in order to our very own studies, the end result from a blended nutrient eating plan rating Hispanic Sites dating sites was not checked.

Objective: We tested associations ranging from consumption regarding magnesium, potassium, and you will calcium and you will likelihood of incident coronary arrest during the 86,149 women in this new Nurses’ Wellness Data (NHS) I and you may 94,715 ladies in the fresh NHS II.

Design: Within possible cohort study, i determined Several hours from coronary arrest by the quintiles out-of consumption for each mineral as well as a mixed diet plan score of the many step 3 minerals that with multivariate Cox proportional hazard activities. On the other hand, i current meta-analyses on the weight-loss consumption ones nutritional elements and chance of coronary arrest.

Results: Through the follow-upwards (29 y from the NHS I; twenty two y from the NHS II) a total of 3780 experience coronary attack cases had been reported. Pooled multivariate RRs off complete coronary arrest for women regarding the highest in contrast to a minimal quintiles was 0.87 (95% CI: 0.78, 0.97) having total magnesium, 0.89 (95% CI: 0.80, 0.99) getting total potassium, and you may 0.97 (95% CI: 0.87, 1.09) to possess complete calcium supplements intake. Pooled RRs for ladies from the large compared with the lowest quintiles of a mixed nutrient eating plan get had been 0.72 (95% CI: 0.65, 0.81) getting overall stroke, 0.78 (95% CI: 0.66, 0.92) getting ischemic coronary arrest, and 0.80 (95% CI: 0.61, 1.04) having hemorrhagic coronary attack. Throughout the current meta-analyses of all the prospective degree to date, the fresh joint RR of overall coronary arrest was 0.87 (95% CI: 0.83, 0.92) getting an one hundred-mg/d escalation in magnesium intake, 0.91 (95% CI: 0.88, 0.94) getting a beneficial one thousand-mg/d escalation in potassium intake, and you will 0.98 (95% CI: 0.94, step one.02) to possess a 300-mg/d upsurge in calcium supplements consumption.

Conclusions: A blended nutrient eating plan rating is actually inversely for the threat of coronary attack. High consumption of magnesium and potassium although not calcium supplements was indeed in addition to somewhat for the less danger of coronary attack in females.

Introduction

Magnesium is an essential mineral and you can cofactor to have >300 enzymatic reactions in the human body ( 1). Magnesium is the next most-numerous intracellular cation close to potassium ( 2). Calcium supplements is among the most-abundant nutrient in the torso. Instance magnesium and you can potassium, calcium supplements is significantly doing work in cardio services ( 3). Higher weight loss intakes of each and every of those nutrition was indeed advertised so you’re able to all the way down danger of blood pressure ( 4– 7), the dominant convertible coronary attack risk factor. not, never assume all possible training checked-out new family members anywhere between fat reduction and you may extra consumption of those nutritional elements and chance of heart attack in women, and you can efficiency was in fact contradictory. Prospective studies from inside the European countries showed magnesium consumption, not consumption off potassium or calcium supplements, try rather in the shorter risk of heart attack ( 7, 8). In the us, consumption regarding potassium and you will magnesium, however out-of calcium supplements, was associated with the smaller coronary arrest risk inside men ( 9), while calcium and you may potassium intakes, although not magnesium intake, was in fact from the smaller coronary arrest exposure in females ( 10). As well as, you to study presented zero total association between these nutritional elements and threat of heart attack ( 11).

Some of the prospective observational degree which were presented failed to were follow-right up past fifteen y and had a comparatively few experience heart attack events, as well as in extremely degree, the fresh independent effectation of for every single nutrient consumption of medicine and you can coronary arrest designs wasn’t examined. In this post, we offer proof on the association of each and every nutrient intake of dieting and tablets with threat of overall, ischemic, and you can hemorrhagic incident strokes. Additionally, i hypothesized you to definitely a mixed diet score of all the 3 nutritional elements tends to be of this faster stroke risk because these vitamins occur together with her for the dishes, and consumption was strongly synchronised. We addressed these types of seeks during the Us ladies who was basically followed prospectively on the dos large cohorts the fresh Nurses’ Fitness Research (NHS) 5 I and you will II.